CU someone preparing a syringe filled with heroin or another opiate. A narrator mentions that large doses of opiates can cause unconsciousness, comas, and death. The syringe is held in front of a styrofoam cup, spoon, matches, and other materials necessary for preparing an injection. Cut to three pedestals representing different classes of depressants (alcohol, sedative-hypnotics, and opioids). Fast zoom to disk representing digestive system as narrator describes effects of depressants on the liver. Taken together, the effects of the drugs may be much greater and more dangerous due to their synergistic qualities. Zoom in on a glass of liquor on nightstand table.